aseboinnovation.blogg.se - Idiosyncratic cell distribution stereology

It is assumed that xenobiotic-inducedĪdverse reactions have a strong genetic basis, but many mechanism-based investigations have not been successful in identifying Interindividual variability in response to chemicals and drugs is a common regulatory concern.

↵ 14 These authors contributed equally to this work.

13 Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA.

12 Hamner-UNC Center for Drug Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina.

11 Purdue Pharma L.P., Stamford, Connecticut 06901, USA.

10 Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA.

9 Verto Institute Research Laboratories, New Brunswick, New Jersey 08903, USA.

8 National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.

7 The Jackson Laboratory, Bar Harbor, Maine 04609, USA.

6 Department of Mouse Genetics, Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.

5 School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA.4 Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.3 Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.2 Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, USA.1 Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.